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1657014-42-0

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1657014-42-0 Structure

1657014-42-0 Structure
IdentificationBack Directory
[Name]

EOS-62353
[CAS]

1657014-42-0
[Synonyms]

EOS-62353
GDC-0575 2HCl
GDC-0575 dihydrochloride
[Molecular Formula]

C16H21BrClN5O
[MDL Number]

MFCD31692377
[MOL File]

1657014-42-0.mol
[Molecular Weight]

414.73
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 65 mg/mL (144.06 mM)
Hazard InformationBack Directory
[Description]

GDC-0575, also known as ARRY-575 and RG7741, is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2?nM. Chk1 inhibitor GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis.
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