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16600-22-9

16600-22-9 Structure

16600-22-9 Structure
IdentificationBack Directory
[Name]

7-CHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID METHYL ESTER
[CAS]

16600-22-9
[Synonyms]

NSC 403048
3-Carbethoxy-4-hydroxy-7-chloroquinoline
Ethyl7-chloro-4-hydroxy-3-quinolinecarboxylate
Ethyl 4-hydroxy-7-chloroquinoline-3-carboxylate
Ethyl 7-chloro-4-hydroxyquinoline-3-carboxylate
ethyl 7-chloro-4-oxo-1H-quinoline-3-carboxylate
Ethyl-7-chloro-1,4-dihydro-4-oxo-3-quinolinecarboxylate
4-Hydroxy-7-chloroquinoline-3-carboxylic acid ethyl ester
7-chloro-4-oxo-1H-quinoline-3-carboxylic acid methyl ester
7-CHLORO-4-HYDROXY-QUINOLINE-3-CARBOXYLIC ACID METHYL ESTER
3-Quinolinecarboxylic acid, 7-chloro-4-hydroxy-, ethyl ester
[Molecular Formula]

C12H10ClNO3
[MDL Number]

MFCD00438741
[MOL File]

16600-22-9.mol
[Molecular Weight]

251.67
Chemical PropertiesBack Directory
[Melting point ]

296-298℃
[Boiling point ]

366.8±37.0 °C(Predicted)
[density ]

1.386
[storage temp. ]

Sealed in dry,Room Temperature
[pka]

2.18±0.50(Predicted)
Safety DataBack Directory
[Symbol(GHS) ]

Health Hazard (GHS08)
GHS08
[Signal word ]

Warning
[Hazard statements ]

H361-H341
[Precautionary statements ]

P501-P202-P201-P280-P308+P313-P405
[HS Code ]

2933499090
Raw materials And Preparation ProductsBack Directory
[Preparation Products]

Ethyl 4,7-dichloroquinoline-3-carboxylate
Hazard InformationBack Directory
[Chemical Properties]

Crystalline compounds. Melting point 297 ℃.
[Uses]

Ethyl 7-chloro-4-hydroxyquinoline-3-carboxylate can be used as an intermediate of chloroquine.
[Synthesis]

Ethyl 7-chloro-4-hydroxyquinoline-3-carboxylate can be obtained by heating and condensing m-chloroaniline and triethyl orthoformate, then condensing with diethyl malonate with the participation of boron trifluoride, and finally heating and cyclizing in paraffin oil.
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