| Identification | More | [Name]
2-ACETYLCYCLOPENTANONE | [CAS]
1670-46-8 | [Synonyms]
2-ACETYLCYCLOPENTANONE
(R,S)-2-Acetyl-cyclopentanone
2-Acetylcyclopentan-1-one
2-acetyl-cyclopentanon
Acetylcyclopentanone
Cyclopentanone, 2-acetyl-
Cyclopentanone,2-acetyl-
o-acetylcyclopentanone
2-ACETYLCYCLOPENTANONE 98+%
2-Acetylcyclopentanone, GC 99% | [EINECS(EC#)]
216-797-5 | [Molecular Formula]
C7H10O2 | [MDL Number]
MFCD00001413 | [Molecular Weight]
126.15 | [MOL File]
1670-46-8.mol |
| Questions And Answer | Back Directory | [Synthesis]
General Procedure: A potassium solution is obtained by contacting a potassium microscope with a THF (0.2 mol/L) solution of 18-crown-6 at -20 °C. An appropriate amount of ketone (THF solution, 1 mol/L) is added dropwise to the resulting blue potassium solution ([K-] = 0.22 mol/L) until the color changes. The obtained cycloalkanone ester and acrylate are then alkylated or acylated. For this purpose, iodomethane or acetyl chloride is added to the enolate under argon atmosphere. The reaction is carried out at room temperature for 60 minutes. The formed potassium halide is separated by filtration. The reaction products are then isolated and analyzed using conventional preparative methods. All compounds obtained had a purity > 96% (GC), and appropriate spectroscopic and analytical data are provided. 2-Acetylcyclopentanone, yield 32%. |
| Chemical Properties | Back Directory | [Appearance]
clear light yellow to brown liquid | [Melting point ]
60-70℃ | [Boiling point ]
72-75 °C/8 mmHg (lit.) | [density ]
1.043 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.489(lit.)
| [Fp ]
163 °F
| [storage temp. ]
2-8°C | [form ]
clear liquid | [pka]
10.87±0.20(Predicted) | [color ]
Colorless to Light yellow to Light orange | [Specific Gravity]
1.043 | [BRN ]
1857601 | [Cosmetics Ingredients Functions]
PERFUMING | [InChI]
1S/C7H10O2/c1-5(8)6-3-2-4-7(6)9/h6H,2-4H2,1H3 | [InChIKey]
OSWDNIFICGLKEE-UHFFFAOYSA-N | [SMILES]
CC(=O)C1CCCC1=O | [LogP]
-0.332 (est) | [CAS DataBase Reference]
1670-46-8(CAS DataBase Reference) | [EPA Substance Registry System]
Cyclopentanone, 2-acetyl- (1670-46-8) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed. | [Safety Statements ]
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
GY4728000
| [F ]
8-10-23 | [TSCA ]
TSCA listed | [HS Code ]
29142900 | [Storage Class]
10 - Combustible liquids |
| Hazard Information | Back Directory | [Chemical Properties]
clear light yellow to brown liquid | [Uses]
2-Acetylcyclopentanone was used to evaluate the protective abilities of 2-ACP in a mouse model of acetaminophen (APAP) hepatotoxicity. | [Purification Methods]
Dissolve the ketone in pet ether (b 30-60o), wash it with saturated aqueous NaHCO3, dry over Drierite and fractionate in a vacuum. It gives a violet colour with ethanolic FeCl3 and is only slowly hydrolysed by 10% aqueous KOH but rapidly on boiling to yield 6-oxoheptanoic acid. [Manyik et al. J Am Chem Soc 75 5030 1953, Acheson J Chem Soc 4232 1956, UV: Martin & Frenelius J Am Chem Soc 81 2342 1959.] It gives a gray green Cu salt from Et2O/pentane, m 237-238o [House & Wasson J Am Chem Soc 79 1488 1957]. |
|
| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Maya High Purity Chemicals
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| Telephone: |
+86 (573) 82222445 (0)18006601000 452520369 |
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www.chemicalbook.com/ShowSupplierProductsList15221/0_EN.htm |
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