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1672665-49-4

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1672665-49-4 Structure

1672665-49-4 Structure
IdentificationBack Directory
[Name]

PT-2385
[CAS]

1672665-49-4
[Synonyms]

CS-2108
PT-2385
PT 2385;PT-2385
Benzonitrile, 3-[[(1S)-2,2-difluoro-2,3-dihydro-1-hydroxy-7-(methylsulfonyl)-1H-inden-4-yl]oxy]-5-fluoro-
[Molecular Formula]

C17H12F3NO4S
[MDL Number]

MFCD28963916
[MOL File]

1672665-49-4.mol
[Molecular Weight]

383.34
Chemical PropertiesBack Directory
[Boiling point ]

524.7±50.0 °C(Predicted)
[density ]

1.57±0.1 g/cm3(Predicted)
[storage temp. ]

Sealed in dry,Store in freezer, under -20°C
[solubility ]

DMSO:50.0(Max Conc. mg/mL);130.43(Max Conc. mM)
[form ]

Solid
[pka]

11.28±0.40(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

PT2385 is a HIF-2α antagonist with EC50 of 27 nM in the luciferase assay, with no apparent off-target effects.
[in vivo]

PT-2385 (30 or 100 mg/kg; oral gavage; twice daily) result in a rapid, dose-dependent tumor regression[3].
PT-2385 (PT2385) inhibits expression of HIF-2α regulated genes in a dose dependent manner in vivo. Tumor is regressed with PT-2385 (3 and 10 mg/kg, p.o., b.i.d. dose) in 786-O xenograft. PT-2385 (1,3 and 10 mg/kg) also inhibits tumor-derived VEGFA protein levels. PT-2385 (10 mg/kg) treatment reduces proliferation (Ki67) and angiogenesis (CD-31)[1].

Animal Model:SCID/beige mice with the 786-O and A498 RCC cell lines[3]
Dosage:30 or 100 mg/kg
Administration:Oral gavage; twice daily
Result:Resulted in a rapid, dose-dependent tumor regression.
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

PT-2385(1672665-49-4)1HNMR
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