| Identification | Back Directory | [Name]
kauran-16,17-diol | [CAS]
16836-31-0 | [Synonyms]
ent-kauran
kauran-16,17-diol
ent-kauran-16β,17-diol
ent-Kaurane-16β,17-diol | [Molecular Formula]
C20H34O2 | [MOL File]
16836-31-0.mol | [Molecular Weight]
306.48 |
| Chemical Properties | Back Directory | [Melting point ]
193-194 °C | [Boiling point ]
422.3±18.0 °C(Predicted) | [density ]
1.09±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
14.48±0.60(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Kauran-16,17-diol (ent-Kauran-16β,17-diol), a natural diterpene, posseses anti-tumor and inducing-apoptosis activity, with a IC50 of 17 μM on inhibiting NO production in LPS-stimulated RAW 264.7 macrophages[1][2]. | [storage]
Store at -20°C | [References]
[1] Alvaro Morales, et al. The natural diterpene ent-16β-17α-dihydroxykaurane down-regulates Bcl-2 by disruption of the Ap-2α/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells. Apoptosis. 2011 Dec;16(12):1245-52. DOI:10.1007/s10495-011-0638-5
[2] Nguyen Xuan Nhiem, et al. New ent-kauranes from the fruits of Annona glabra and their inhibitory nitric oxide production in LPS-stimulated RAW264.7 macrophages. Bioorg Med Chem Lett. 2015 Jan 15;25(2):254-8. DOI:10.1016/j.bmcl.2014.11.059 |
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| Company Name: |
Bide Pharmatech Ltd.
|
| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
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