| Identification | Back Directory | [Name]
Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)- | [CAS]
168682-53-9 | [Synonyms]
CS-1110
Ezatiostat
Terrapin 199
Ezatiostat, >96%
TER199(free base)
Ezatiostat, >=98%
Ezatiostat (TER199)
Ezatiostat TFA (free base)
TER 199; TLK-199; TELINTRA
(2R)-L-gamma-Glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenylglycine 1,3-diethyl ester
Glycine, L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,1,3-diethyl ester, (2R)-
Glycine, L-γ-glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenyl-, 1,3-diethyl ester, (2R)-
(S)-ETHYL 2-AMINO-5-((R)-3-(BENZYLTHIO)-1-((R)-2-ETHOXY-2-OXO-1-PHENYLETHYLAMINO)-1-OXOPROPAN-2-YLAMINO)-5-OXOPENTANOATE | [Molecular Formula]
C27H35N3O6S | [MDL Number]
MFCD27982957 | [MOL File]
168682-53-9.mol | [Molecular Weight]
529.65 |
| Chemical Properties | Back Directory | [Melting point ]
>94°C (dec.) | [Boiling point ]
749.7±60.0 °C(Predicted) | [density ]
1.216±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
12?+-.0.46(Predicted) | [color ]
White to Off-White | [InChIKey]
FXTMNDVNPLUYKX-OKIYALLLNA-N | [SMILES]
C(OCC)(=O)[C@@H](C1=CC=CC(CC)=C1)N(C(=O)CC[C@@H](C(O)=O)N)C(=O)[C@H](CSCC1=CC=CC=C1)N |&1:5,19,26,r| |
| Hazard Information | Back Directory | [Description]
Ezatiostat is an inhibitor of glutathione S-transferase pi 1-1 (GSTP1-1; Ki = 0.4 μM). It is selective for GSTP1-1 over GSTα and GSTμ family GSTs (Kis = 20-75 μM). Ezatiostat also inhibits the protein-protein interaction between GSTP1-1 and JNK1. In vivo, ezatiostat (75 mg/kg) increases the number of circulating white blood cells in Gstp1 wild-type, but not Gstp1-/-, mice. | [Uses]
Ezatiostat is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1, the most prevalent Glutathione S-transferases (GST) isozyme in nonhepatic tissues, catalytic activity with minimal effect on the related GSTα and -μ families. | [in vivo]
Administration of Ezatiostat (TLK199), stimulates both lymphocyte production and bone marrow progenitor (colony-forming unit-granulocyte macrophage) proliferation, but only in glutathione S-transferase P1-1 (GSTP1+/+) and not in GSTP1-/-animals[2]. | [target]
Gutathione S-transferase | [References]
[1] JACOB S. YOUNT Howard C H Mingzi M Zhang. Visualization and Identification of Fatty Acylated Proteins Using Chemical Reporters[J]. Current protocols in chemical biology, 2011, 3 2. DOI: 10.1002/9780470559277.ch100225 |
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