| Identification | Back Directory | [Name]
L-gamma-Glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenylglycine diethyl ester monohydrochloride | [CAS]
286942-97-0 | [Synonyms]
TLK 199
Telintra
TLK199 HCl
Ezatiostat HCl
Unii-D59N834676
TLK199 hydrochloride
Ezatiostat (TER199) HCl
Ezatiostat hydrochloride
Ezatiostat (TER199) hydrochloride
gamma-Glu-S-bzcys-phgly diethyl ester
Glycine,L-g-glutaMyl-S-(phenylMethyl)-L-cysteinyl-2-phenyl-,diethyl ester, Monohydrochloride
L-gamma-Glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenylglycine diethyl ester monohydrochloride
L-gamma-Glutamyl-S-(phenylmethyl)-L-cysteinyl-D-phenylglycine diethyl ester monohydrochloride
L-gamma-Glutamyl-S-(phenylmethyl)-L-cysteinyl-2-phenylglycine diethyl ester monohydrochloride USP/EP/BP
ethyl(2S)-2-amino-5-[[(2R)-3-benzylsulfanyl-1-[[(1R)-2-ethoxy-2-oxo-1-phenylethyl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoate,hydrochloride | [Molecular Formula]
C27H35N3O6S.ClH | [MDL Number]
MFCD03701300 | [MOL File]
286942-97-0.mol | [Molecular Weight]
566.115 |
| Hazard Information | Back Directory | [Uses]
Ezatiostat hydrochloride (TER199; TLK199 hydrochloride) is a tripeptide analog of glutathione and is a selective and orally active glutathione S-transferase P1-1 (GSTP1) inhibitor. Ezatiostat hydrochloride leads to JNK activation by inhibiting GSTP1. Ezatiostat hydrochloride stimulates both lymphocyte production and bone marrow progenitor proliferation. Ezatiostat hydrochloride has the potential for myelodysplastic syndrome (MDS) treatment[1][2]. | [in vivo]
Administration of Ezatiostat (TLK199), stimulates both lymphocyte production and bone marrow progenitor (colony-forming unit-granulocyte macrophage) proliferation, but only in glutathione S-transferase P1-1 (GSTP1+/+) and not in GSTP1-/-animals[2]. | [References]
[1] Galili N, et al. Prediction of response to therapy with ezatiostat in lower risk myelodysplastic syndrome. J Hematol Oncol. 2012 May 6;5:20 DOI:10.1186/1756-8722-5-20
[2] Ruscoe JE, et al. Pharmacologic or genetic manipulation of glutathione S-transferase P1-1 (GSTpi) influences cell proliferation pathways. J Pharmacol Exp Ther. 2001 Jul;298(1):339-45. PMID:11408560 |
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