| Identification | Back Directory | [Name]
Tos-PEG5-CH2CO2t-butyl ester | [CAS]
169751-73-9 | [Synonyms]
Tos-PEG4-CH2-Boc
Tos-PEG4-CH2COOtBu
Tos-PEG5-CH2CO2tBu
Tos-PEG5-CH2CO2t-butyl ester
tert-butyl 2-[2-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]ethoxy]acetate
2-(2-{2-[2-(Toluene-4-sulfonyloxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-acetic acid tert-butyl ester
3,6,9,12-Tetraoxatetradecanoic acid, 14-[[(4-methylphenyl)sulfonyl]oxy]-, 1,1-dimethylethyl ester | [Molecular Formula]
C21H34O9S | [MDL Number]
MFCD27977499 | [MOL File]
169751-73-9.mol | [Molecular Weight]
462.55 |
| Hazard Information | Back Directory | [Description]
Tos-PEG5-CH2CO2tBu is a PEG linker containing a t-butyl ester and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions. | [Uses]
Tos-PEG4-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34. DOI:10.1038/s12276-018-0065-6 |
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