| Identification | Back Directory | [Name]
Tos-PEG3-t-butyl ester | [CAS]
850090-13-0 | [Synonyms]
CAS_850090-13-0
Tos-PEG2-C2-Boc
Tos-PEG2-COOtBu
Tos-PEG2-CH2CH2COOtBu
Tos-PEG3-t-butyl ester
tert-butyl 3-(2-(2-(tosyloxy)ethoxy)ethoxy)propanoate
9-(p-toluenesulfonyloxy)-3,6-diocanonanoic acid tert-butyl ester
Propanoic acid, 3-[2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]ethoxy]-, 1,1-dimethylethyl ester | [Molecular Formula]
C18H28O7S | [MDL Number]
MFCD27635184 | [MOL File]
850090-13-0.mol | [Molecular Weight]
388.48 |
| Hazard Information | Back Directory | [Description]
Tos-PEG3-t-butyl ester is a PEG linker containing a t-butyl ester and a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. The tosyl group is a very good leaving group for nucleophilic substitution reactions. | [Uses]
Tos-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34. DOI:10.1038/s12276-018-0065-6 |
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