| Identification | Back Directory | [Name]
Vipivotide tetraxetan Linker | [CAS]
1703768-74-4 | [Synonyms]
PSMA-617 Linker
Vipivotide tetraxetan Linker
VIPIVOTIDE TETRAXETAN LINKER;PSMA-617 LINKER
L-Lysine, N6-[N-[[trans-4-(aminomethyl)cyclohexyl]carbonyl]-3-(2-naphthalenyl)-L-alanyl]-N2-[[[(1S)-1,3-dicarboxypropyl]amino]carbonyl]- | [Molecular Formula]
C33H45N5O9 | [MDL Number]
MFCD32197316 | [MOL File]
1703768-74-4.mol | [Molecular Weight]
655.74 |
| Chemical Properties | Back Directory | [Boiling point ]
1063.2±65.0 °C(Predicted) | [density ]
1.303±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
3.78±0.10(Predicted) | [color ]
White to off-white | [InChIKey]
JHWCOTSIOATVKA-UIGMUVSQSA-N | [SMILES]
C(O)(=O)[C@H](CCCCNC(=O)[C@H](CC1=CC=C2C(=C1)C=CC=C2)NC([C@@H]1CC[C@@H](CN)CC1)=O)NC(N[C@H](C(O)=O)CCC(O)=O)=O |
| Hazard Information | Back Directory | [Uses]
Vipivotide tetraxetan Ligand-Linker Conjugate (PSMA-617 Ligand-Linker Conjugate) is a complex composed of pharmacophore group Glutamate-urea-Lysine peptide coupling linker, which can be used to synthesize Vipivotide tetraxetan (PSMA-617). Glutamate-urea-Lysine selectively binds to prostate-specific membrane antigen (PSMA)[1]. | [IC 50]
Non-cleavable Linker | [References]
[1] Bene?ová M, et al. Albumin-Binding PSMA Ligands: Optimization of the Tissue Distribution Profile. Mol Pharm. 2018 Mar 5;15(3):934-946. DOI:10.1021/acs.molpharmaceut.7b00877 |
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