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170686-10-9

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170686-10-9 Structure

170686-10-9 Structure
IdentificationBack Directory
[Name]

BMS-196085
[CAS]

170686-10-9
[Synonyms]

BMS-196085
FM0D5L3W03
CHEMBL322862
SCHEMBL7042488
Methanesulfonamide, N-[5-[(1R)-2-[[(1R)-1-[4-(difluoromethoxy)phenyl]-2-phenylethyl]amino]-1-hydroxyethyl]-2-hydroxyphenyl]-
[Molecular Formula]

C24H26F2N2O5S
[MOL File]

170686-10-9.mol
[Molecular Weight]

492.54
Chemical PropertiesBack Directory
[Boiling point ]

645.7±65.0 °C(Predicted)
[density ]

1.373±0.06 g/cm3(Predicted)
[pka]

10.89±0.50(Predicted)
Hazard InformationBack Directory
[Uses]

BMS-196085 is an orally active, potent and selective full agonist against human β3 adrenergic receptor with a Ki value of 21 nM. BMS-196085 also has partial agonist activity at the β1 receptor. BMS-196085 is promising for research of obesity and type-II diabetes[1][2].
[References]

[1] Gavai A V, et al. BMS-196085: a potent and selective full agonist of the human β3 adrenergic receptor[J]. Bioorganic & medicinal chemistry letters, 2001, 11(23): 3041-3044.
[2] Hu B, et al. Orally bioavailable β3-adrenergic receptor agonists as potential therapeutic agents for obesityand type-II diabetes[J]. Progress in medicinal chemistry, 2003, 41: 167-194.
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Website: https://www.targetmol.cn/
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