170686-10-9

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170686-10-9 Structure

Identification	Back Directory
[Name] BMS-196085
[CAS] 170686-10-9
[Synonyms] BMS-196085 FM0D5L3W03 CHEMBL322862 SCHEMBL7042488 Methanesulfonamide, N-[5-[(1R)-2-[[(1R)-1-[4-(difluoromethoxy)phenyl]-2-phenylethyl]amino]-1-hydroxyethyl]-2-hydroxyphenyl]-
[Molecular Formula] C24H26F2N2O5S
[MOL File] 170686-10-9.mol
[Molecular Weight] 492.54

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[Uses] BMS-196085 is an orally active, potent and selective full agonist against human β3 adrenergic receptor with a Ki value of 21 nM. BMS-196085 also has partial agonist activity at the β1 receptor. BMS-196085 is promising for research of obesity and type-II diabetes[1][2].
[References] [1] Gavai A V, et al. BMS-196085: a potent and selective full agonist of the human β3 adrenergic receptor[J]. Bioorganic & medicinal chemistry letters, 2001, 11(23): 3041-3044. [2] Hu B, et al. Orally bioavailable β3-adrenergic receptor agonists as potential therapeutic agents for obesityand type-II diabetes[J]. Progress in medicinal chemistry, 2003, 41: 167-194.

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