| Identification | Back Directory | [Name]
Cyasterone | [CAS]
17086-76-9 | [Synonyms]
cyasteron
CYASTERONE
(22r,24s,25s,28r)-gamma-lacton
Cyasterone, 98%, from Cyathula officinalis K.C. Kuan
2-beta,3-beta,14,20,22,28-hexahydroxy-6-oxo-5-beta-stigmast-7-en-26-oicaci
(22R,24S,25S,28R)-2β,3β,14,20,22,28-Hexahydroxy-6-oxo(26-13C)-5β-stigmasta-7-ene-26-oic acid γ-lactone
7,(5BETA)-CHOLESTEN-26-CARBOXYLIC ACID-24BETA-(1-HYDROXYETHYL)-2BETA, 3BETA, 14ALPHA,20BETA, 22R-PENTOL-6-ONE GAMMA-LACTONE
(3S,4S,5R)-4-[(2R,3R)-2,3-Dihydroxy-3-[(2S,3R,5R,9R,10R,13R,14S,17S)-2,3,14-trihydroxy-10,13-dimethyl-6-oxo-2,3,4,5,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]butyl]-3,5-dimethyloxolan-2-one | [Molecular Formula]
C29H44O8 | [MDL Number]
MFCD00468110 | [MOL File]
17086-76-9.mol | [Molecular Weight]
520.65 |
| Chemical Properties | Back Directory | [Melting point ]
164～166℃ | [Boiling point ]
735.2±60.0 °C(Predicted) | [density ]
1.31±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
14.12±0.70(Predicted) | [color ]
White to off-white | [InChIKey]
NEFYSBQJYCICOG-YSEUJXISSA-N | [SMILES]
O=C1[C@]2([H])C[C@@H](O)[C@@H](O)C[C@]2(C)[C@](CC[C@@]3(C)[C@@]4(O)CC[C@]3([H])[C@](O)(C)[C@H](O)C[C@H]5[C@H](C)C(O[C@@H]5C)=O)([H])C4=C1 |
| Hazard Information | Back Directory | [Chemical Properties]
White crystals, soluble in methanol, ethanol, and DMSO, derived from the dried roots of Cyathula officinalis Kuan. | [Uses]
Cyasterone is a phytoecdysteroid that has been shown to prevent the hepatotoxic action of CCl4 when administered to rats with hepatitis. | [Definition]
ChEBI: Cyasterone is a steroid lactone, a 21-hydroxy steroid, a 2beta-hydroxy steroid, a 3beta-hydroxy steroid, a 14alpha-hydroxy steroid, a 20-hydroxy steroid, a 6-oxo steroid and a phytoecdysteroid. | [in vivo]
Cyasterone (intraperitoneal injection; 5 mg/kg, 10 mg/kg and 15 mg/kg; 21 days) has anti-proliferation effect in vivo and inhibits MGC823 cells xenografted tumor growth in vivo with few changes in body weights[2]. | Animal Model: | MGC823 xenograft tumor in BALB/C-nu mice[1] | | Dosage: | 5 mg/kg, 10 mg/kg and 15 mg/kg | | Administration: | Intraperitoneal injection | | Result: | Inhibited MGC823 xenograft tumor growth in vivo. |
|
|
|