| Identification | Back Directory | [Name]
TRYPROSTATIN A | [CAS]
171864-80-5 | [Synonyms]
TPS-A
TRYPROSTATIN A
TRYPROSTATIN B
Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-[[6-methoxy-2-(3-methyl-2-buten-1-yl)-1H-indol-3-yl]methyl]-, (3S,8aS)- | [Molecular Formula]
C22H27N3O3 | [MDL Number]
MFCD01862627 | [MOL File]
171864-80-5.mol | [Molecular Weight]
381.47 |
| Chemical Properties | Back Directory | [Melting point ]
119-120 °C | [Boiling point ]
666.4±55.0 °C(Predicted) | [density ]
1.26±0.1 g/cm3(Predicted) | [form ]
White powder. | [pka]
12.99±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
Tryprostatin A is an inhibitor of the mammalian cell cycle. Tryprostatins A can be isolated from the secondary metabolites of a marine fungal strain BM939[1]. | [Definition]
ChEBI: Tryprostatin A is a cyclic dipeptide that is brevianamide F (cyclo-L-Trp-L-Pro) substituted at positions 2 and 6 on the indole ring by prenyl and methoxy groups respectively. It has a role as a breast cancer resistance protein inhibitor. It is a dipeptide, a member of indoles, a pyrrolopyrazine, an aromatic ether and an indole alkaloid. It is functionally related to a brevianamide F. | [References]
[1] CHENG-BIN CUI, et al. Tryprostatins A and B, Novel Mammalian Cell Cycle Inhibitors Produced by Aspergillus fumigatus. The Journal of Antibiotics. 1995, 48. |
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