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172489-10-0

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172489-10-0 Structure

172489-10-0 Structure
IdentificationBack Directory
[Name]

2-Pyrrolidinone, 1-[(2R)-2-(1,3-dioxolan-2-yl)-2-methyl-6-nitro-2H-1-benzopyran-4-yl]-
[CAS]

172489-10-0
[Synonyms]

SKP450
SKP-450
SKP 450
KR30450
KR-30450
KR 30450
2-Pyrrolidinone, 1-[(2R)-2-(1,3-dioxolan-2-yl)-2-methyl-6-nitro-2H-1-benzopyran-4-yl]-
[Molecular Formula]

C17H18N2O6
[MOL File]

172489-10-0.mol
[Molecular Weight]

346.33
Chemical PropertiesBack Directory
[Boiling point ]

573.2±50.0 °C(Predicted)
[density ]

1.423±0.06 g/cm3(Predicted)
[pka]

-0.82±0.20(Predicted)
Hazard InformationBack Directory
[Uses]

KR-30450 (SKP 450) is a potent K+ATP opener, and a potassium channel activator. KR-30450 exerts more potent cardioprotective effects than Lemakalim (HY-14255). KR-30450 significantly improves reperfusion cardiac function. KR-30450 significantly attenuates reperfusion contracture and lactate dehydrogenase release[1].
[References]

[1] Jung YS, et al. Cardioprotective effects of KR-30450, a novel K+(ATP) opener, and its major metabolite KR-30818 on isolated rat hearts. Jpn J Pharmacol. 1998 Jan;76(1):65-73. DOI:10.1254/jjp.76.65
172489-10-0 suppliers list
Company Name: TargetMol Chemicals Inc.  
Telephone: 15002134094
Website: https://www.targetmol.cn/
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