| Identification | Back Directory | [Name]
2-Pyrrolidinone, 1-[(2R)-2-(1,3-dioxolan-2-yl)-2-methyl-6-nitro-2H-1-benzopyran-4-yl]- | [CAS]
172489-10-0 | [Synonyms]
SKP450
SKP-450
SKP 450
KR30450
KR-30450
KR 30450
2-Pyrrolidinone, 1-[(2R)-2-(1,3-dioxolan-2-yl)-2-methyl-6-nitro-2H-1-benzopyran-4-yl]- | [Molecular Formula]
C17H18N2O6 | [MOL File]
172489-10-0.mol | [Molecular Weight]
346.33 |
| Hazard Information | Back Directory | [Uses]
KR-30450 (SKP 450) is a potent K+ATP opener, and a potassium channel activator. KR-30450 exerts more potent cardioprotective effects than Lemakalim (HY-14255). KR-30450 significantly improves reperfusion cardiac function. KR-30450 significantly attenuates reperfusion contracture and lactate dehydrogenase release[1]. | [References]
[1] Jung YS, et al. Cardioprotective effects of KR-30450, a novel K+(ATP) opener, and its major metabolite KR-30818 on isolated rat hearts. Jpn J Pharmacol. 1998 Jan;76(1):65-73. DOI:10.1254/jjp.76.65 |
|
|