| Identification | Back Directory | [Name]
BUFORIN II | [CAS]
172998-24-2 | [Synonyms]
BUFORIN II
L-Threonyl-L-arginyl-L-seryl-L-seryl-L-arginyl-L-alanylglycyl-L-leucyl-L-glutaminyl-L-phenylalanyl-L-prolyl-L-valylglycyl-L-arginyl-L-valyl-L-histidyl-L-arginyl-L-leucyl-L-leucyl-L-arginyl-L-lysine | [Molecular Formula]
C106H184N40O26 | [MDL Number]
MFCD01311893 | [MOL File]
172998-24-2.mol | [Molecular Weight]
2434.85 |
| Hazard Information | Back Directory | [Uses]
Buforin II, derived from buforin I, a protein isolated from the stomach of the Asian toad Bufo bufo gargarizans, is a potent antimicrobial peptide. Buforin II has antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria[1]. | [in vivo]
Buforin II (intravenously a single dose, 1 mg/kg) has potent antibacterial activity that effectively reduces lethality and leads to a significant reduction in plasma endotoxin and cytokine concentrations in male Wistar rat model of sepsis[1].
| Animal Model: | Male Wistar rats weighing 200 to 300 g with A. baumannii?ATCC 19606[1] | | Dosage: | 1 mg/kg | | Administration: | Intravenously a single dose | | Result: | Reduced mortality by 40% in the treatment group and by 20% in the rifampicin (10 mg/kg) combination group.
Reduced TNF, IL-6 and endotoxin plasma levels by 33%, 25% and 32%, respectively. |
| Animal Model: | Male Wistar rats weighing 200 to 300 g with the multiresistant strain[1] | | Dosage: | 1 mg/kg | | Administration: | Intravenously a single dose | | Result: | Reduced mortality by 46.6% in the treatment group and by 20% in the rifampicin (10 mg/kg) combination group.
Reduced TNF, IL-6 and endotoxin plasma levels by 46%, 20% and 28%, respectively. |
| [References]
[1] Oscar Cirioni, et al. Therapeutic efficacy of buforin II and rifampin in a rat model of Acinetobacter baumannii sepsis. Crit Care Med. 2009 Apr;37(4):1403-7. DOI:10.1097/CCM.0b013e31819c3e22 |
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