| Identification | More | [Name]
2-Bromo-4-methoxybenzenol | [CAS]
17332-11-5 | [Synonyms]
2-BROMO-4-METHOXYBENZENOL
2-BROMO-4-METHOXYPHENOL
2-bromo-4-methoxylphenol
3-Bromo-4-hydroxyanisole
2-Bromo-4-methoxyphenol ,98%
4-Methoxy-2-bromophenol | [Molecular Formula]
C7H7BrO2 | [MDL Number]
MFCD02113712 | [Molecular Weight]
203.03 | [MOL File]
17332-11-5.mol |
| Chemical Properties | Back Directory | [Melting point ]
47 | [Boiling point ]
115 °C | [density ]
1.585±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
powder to crystal | [pka]
8.92±0.18(Predicted) | [color ]
White to Light yellow to Light orange | [Detection Methods]
HPLC,NMR | [CAS DataBase Reference]
17332-11-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [Hazard Note ]
Irritant | [HS Code ]
29071990 |
| Hazard Information | Back Directory | [Chemical Properties]
Off-white solid | [Synthesis]
General procedure for the synthesis of 2-bromo-4-methoxyphenol from p-hydroxyanisole: 2.6 mL (100 mMol) of bromine dissolved in 10 mL of carbon disulfide was slowly added dropwise to 12.4 g (100 mMol) of 4-methoxyphenol dissolved in 20 mL of carbon disulfide at 0 °C. The reaction temperature was maintained at 30 °C. After 30 min, 1 mL of bromine dissolved in 10 mL of carbon disulfide was added dropwise. The reaction temperature was maintained at 30 °C. After 30 min, 1 mL of the solution of bromine dissolved in 10 mL of carbon disulfide was added dropwise. After completion of the reaction, the mixture was concentrated under reduced pressure. The residue was dissolved in ether and washed sequentially with 100 mL of water and 100 mL of saturated aqueous sodium chloride. The organic phase was dried with magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography using a gradient elution with hexane containing 0 to 20% ethyl acetate. The fractions containing the target product were combined and concentrated under reduced pressure to give 11.6 g (57% yield) of 2-bromo-4-methoxyphenol as a crystalline solid.1H-NMR (CDCl3): δ 7.0 (d, 1H), 6.95 (d, 1H), 6.8 (dd, 1H), 5.15 (s, 1H), 3.75 (s, 3H). | [References]
[1] Organic Letters, 2004, vol. 6, # 4, p. 457 - 460
[2] Synthetic Communications, 2007, vol. 37, # 2, p. 323 - 328
[3] Chemistry - A European Journal, 2012, vol. 18, # 11, p. 3286 - 3291
[4] Chemical Communications, 2012, vol. 48, # 52, p. 6577 - 6579
[5] Patent: WO2013/97224, 2013, A1. Location in patent: Page/Page column 72 |
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