| Identification | Back Directory | [Name]
Amiloride hydrochloride dihydrate | [CAS]
17440-83-4 | [Synonyms]
Modamide
AMilorida
Amiloride hydrochlorid
AMiloride hydrocholride
AMILORIDE HCL DIHYDRATE
AMILORIDEHYDROCHLORIDE,USP
MK-870 hydrochloride dihydrate
Miloride hydrochloride dihydrate
AMILORIDE HYDROCHLORIDE (500 MG)
Amiloride HCl dihydrate (MK 870)
Amiloride hydrochloride dihydrate
AMILORIDE HYDROCHLORIDE 2-HYDRATE
Amiloride Hydrochloride(HCl 2H20)
Amiloride ,Amiloride Hydrochloride
Amiloride hydrochloride dihydrate USP/EP/BP
Amiloride for peak identification (Y0001902)
TIANFU-CHEM 17440-83-4 Amiloride hydrochloride dihydrate
3,5-Diamino-N-(aminomethyl)-6-chloropyrazine carboxamide hydrochloride dihydrate
3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide hydrochloride dihydrate
Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, monohydrochloride, dihydrate
3,5-diamino-N-(aminoiminomethyl)-6-chloro-2-pyrazinecarboxamide, hydrochloride, hydrate (1:1:2) | [EINECS(EC#)]
217-958-2 | [Molecular Formula]
C6H8ClN7O.HCl.2H2O | [MDL Number]
MFCD00211292 | [MOL File]
17440-83-4.mol | [Molecular Weight]
302.12 |
| Chemical Properties | Back Directory | [Appearance]
Pale yellow or greenish-yellow powder. | [Melting point ]
>240℃ | [RTECS ]
UQ2275500 | [storage temp. ]
Store at -20°C | [solubility ]
Slightly soluble in water and in anhydrous ethanol. | [form ]
neat | [pka]
8.7(at 25℃) | [color ]
Off-white to yellow | [Water Solubility ]
Soluble in water at 50mg/ml | [Major Application]
pharmaceutical | [InChI]
InChI=1S/C6H8ClN7O.ClH.2H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;;/h(H4,8,9,13)(H4,10,11,14,15);1H;2*1H2 | [InChIKey]
LTKVFMLMEYCWMK-UHFFFAOYSA-N | [SMILES]
C1(C(NC(N)=N)=O)=NC(Cl)=C(N)N=C1N.[H]Cl.[H]O[H].[H]O[H] |
| Hazard Information | Back Directory | [Chemical Properties]
Pale yellow or greenish-yellow powder. | [Uses]
An epithelial sodium channel blocker | [Uses]
Diuretic;Antialdosteron | [Definition]
ChEBI: A hydrate that is the dihydrate of amiloride hydrochloride. | [Brand name]
Midamor (Merck). | [in vivo]
Amiloride hydrochloride dihydrate is a potent epithelial sodium channels (ENaCs) blocker. Amiloride is highly concentrated in the plasma 15 to 30 minutes following the injections. 2 mg/kg dose of Amiloride hydrochloride dihydrate has no effect on blood pressure, heart rate, mesenteric vascular resistance, or hindquarters vascular resistance as compare to the baseline measurements (n=7). Over a 2 hour period, Amiloride hydrochloride dihydrate elicits negligible responses in arterial pressure (-1±1 mmHg) and heart rate (-10±6 bpm/min) as compare to baseline levels. Results show an Amiloride hydrochloride dihydrate dose-related response pattern for the c-Fos activation in the area postrema (AP). Even at the lowest dose of Amiloride hydrochloride dihydrate (0.1 mg/kg), the number of c-Fos labeled neurons in the AP is statistically different from the control rats at a p<0.01 level[1]. |
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