| Identification | Back Directory | [Name]
Glyoxalase I inhibitor (free base) | [CAS]
174568-92-4 | [Synonyms]
Glyoxalase I inhibitor (free base)
Glycine, L-γ-glutamyl-S-[[(4-bromophenyl)hydroxyamino]carbonyl]-L-cysteinyl-, diethyl ester (9CI) | [Molecular Formula]
C21H29BrN4O8S | [MDL Number]
MFCD29924004 | [MOL File]
174568-92-4.mol | [Molecular Weight]
577.45 |
| Chemical Properties | Back Directory | [density ]
1.480±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light, stored under nitrogen | [solubility ]
DMSO:110.0(Max Conc. mg/mL);190.49(Max Conc. mM) | [form ]
Solid | [pka]
7.31±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Glyoxalase I inhibitor free base (3(Et)2) is the inhibitor for glyoxalase I (GLO), and can be used in antitumor research[1].
In Vitro:Glyoxalase I inhibitor free base (100 μM, 48 h) inhibits glyoxalase I, causes accumulation of methylglyoxal and leads to cytotoxicity in cells L1210 and B16 with GI50 of 3 μM and 11 μM[1]. | [storage]
4°C, protect from light, stored under nitrogen | [References]
[1] Kavarana MJ, et al., Mechanism-based competitive inhibitors of glyoxalase I: intracellular delivery, in vitro antitumor activities, and stabilities in human serum and mouse serum. J Med Chem. 1999 Jan 28;42(2):221-8. DOI:10.1021/jm9708036 |
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