| Identification | More | [Name]
L-DAB HBR | [CAS]
1758-80-1 | [Synonyms]
L-2,4-DIAMINOBUTYRIC ACID HYDROBROMIDE
L-DAB HBR
L-DAB HYDROBROMIDE
L-Dab•
L-2,4-Diaminobutanoate
H-DabHBr
(S)-2,4-Diaminobutyric acid
L-DABA | [Molecular Formula]
C4H11BrN2O2 | [MDL Number]
MFCD07368664 | [Molecular Weight]
199.05 | [MOL File]
1758-80-1.mol |
| Hazard Information | Back Directory | [Uses]
L-DABA (L-2,4-Diaminobutyric acid) is a week GABA transaminase inhibitor with an IC50 of larger than 500 μM; exhibits antitumor activity in vivo and in vitro. | [Definition]
ChEBI: A 2,4-diaminobutyric acid that has S-configuration. | [in vivo]
Treatment with L-DABA results in 43.4% reduction of tumor growth[1]. L-DABA is a more effective inhibitor of GABA transaminase in vivo than in vitro[2]. | [IC 50]
Human Endogenous Metabolite | [References]
[1] Ronquist G, et al. Antitumor activity of L-2,4 diaminobuturic acid against mouse fibrosarcoma cells in vitro and in vivo. J Cancer Res Clin Oncol. 1980;96(3):259-68. DOI:10.1007/BF00408098
[2] Beart PM, et al. l-2,4-Diaminobutyric acid and the GABA system. Neurosci Lett. 1977 Jul;5(3-4):193-8. DOI:10.1016/0304-3940(77)90046-5
[3] Panasci L, et al. The cytolytic effect of L-2,4 diaminobutyric acid with malignant glioma cells and fibroblasts. Cancer Chemother Pharmacol. 1988;21(2):143-4. DOI:10.1007/BF00257361 |
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