| Identification | Back Directory | [Name]
BMS 193884 | [CAS]
176960-47-7 | [Synonyms]
BMS 193884
[1,1'-Biphenyl]-2-sulfonamide, N-(3,4-dimethyl-5-isoxazolyl)-4'-(2-oxazolyl)- | [Molecular Formula]
C20H17N3O4S | [MOL File]
176960-47-7.mol | [Molecular Weight]
395.43 |
| Hazard Information | Back Directory | [Uses]
BMS-193884 is a selective, orally active, and competitive ETA antagonist with 10000-fold greater affinity for the human ETA receptor (Ki=1.4 nM) than for the ETB receptor[1]. | [IC 50]
ETA: 1.4 nM (Ki); ETB: 18700 nM (Ki) | [References]
[1] Murugesan N, et al. Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET(A) selective antagonist. J Med Chem. 2003;46(1):125-137. DOI:10.1021/jm020289q |
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