| Identification | Back Directory | [Name]
1777832-90-2 | [CAS]
1777832-90-2 | [Synonyms]
BAL3833
TBAP-001
BAL3833(TBAP-001)
pancreatic,TBAP-001,lung,Raf kinases,melanoma,Raf,inhibit,TBAP001,TBAP 001,carcinoma,Inhibitor,colorectal
1-(3-(tert-butyl)-1-(3-fluorophenyl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-((3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yl)oxy)phenyl)urea
Urea, N-[4-[(3,4-dihydro-3-oxopyrido[2,3-b]pyrazin-8-yl)oxy]-2-fluorophenyl]-N'-[3-(1,1-dimethylethyl)-1-(3-fluorophenyl)-1H-pyrazol-5-yl]- | [Molecular Formula]
C27H23F2N7O3 | [MDL Number]
MFCD32857166 | [MOL File]
1777832-90-2.mol | [Molecular Weight]
531.51 |
| Hazard Information | Back Directory | [Uses]
TBAP-001 (Synthesis 13), extracted from patent WO2015075483A1, is a pan-RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay[1]. | [References]
[1] Caroline Joy, et al. 1 -(5-TERT-BUTYL-2-ARYL-PYRAZOL-3-YL)-3-[2-FLUORO-4-[(3-OXO-4H-PYRIDO[2, |
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