| Identification | Back Directory | [Name]
CLORGYLINE HYDROCHLORIDE | [CAS]
17780-75-5 | [Synonyms]
Clorgyline HCl
CLORGYLINE HYDROCHLORIDE
Clorgiline (hydrochloride)
N-methyl-N-propargyl-3-(2,4-*dichlorophenoxy)prop
N-METHYL-N-PROPARGYL-3-(2,4-*DICHLOROPHE NOXY)PROPYL
N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine
3-(2,4-dichlorophenoxy)-n-methyl-n-propargyl-propylaminhydrochloride
N-METHYL-N-PROPARGYL-3-(2,4-DICHLOROPHENOXY)-PROPYLAMINE HYDROCHLORIDE
n-(3-(2,4-dichlorophenoxy)propyl)-n-methyl-2-propynylaminhydrochloride
n-(3-(2,4-dichlorophenoxy)propyl)-n-methyl-2-propyn-1-aminhydrochloride
N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-2-propynylamine hydrochloride
N-(3-(2,4-dichlorophenoxy)propyl)-N-methylprop-2-yn-1-amine hydrochloride
3-(2,4-dichlorophenoxy)-n-Methyl-n-prop-2-ynylpropan-1-aMine hydrochloride
2-Propyn-1-aMine, N-[3-(2,4-dichlorophenoxy)propyl]-N-Methyl-, hydrochloride
N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride >=97% (GC)
N-Methyl-N-propargyl-3-(2,4-dichlorophenoxy)propylamine hydrochloride,Clorgyline | [EINECS(EC#)]
241-760-5 | [Molecular Formula]
C13H16Cl3NO | [MDL Number]
MFCD00052012 | [MOL File]
17780-75-5.mol | [Molecular Weight]
308.63 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
≥17.65 mg/mL in DMSO; ≥18.2 mg/mL in EtOH; ≥24.8 mg/mL in H2O | [form ]
A crystalline solid | [color ]
White to off-white |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
20/21/22 | [Safety Statements ]
36 | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
UI0675000
| [HazardClass ]
6.1(b) | [PackingGroup ]
III |
| Hazard Information | Back Directory | [Description]
Clorgyline is a potent monoamine oxidase (MAO) inhibitor that preferentially targets MAO-A over MAO-B (Kis = 0.054 and 58 μM, respectively). This inhibition is irreversible. Clorgyline is without effect on serotonin receptors, but it does inhibit the sigma receptor σ1 on Jurkat human T lymphocyte cells (IC50 = 31 nM). As MAO-A preferentially oxidizes serotonin, selective MAO-A inhibitors have applications in ameliorating depression and anxiety. | [Uses]
Antidepressant;Monoamine oxidase A inhibitor | [Biochem/physiol Actions]
MAO-A inhibitor. | [in vivo]
Clorgyline hydrochloride (2 mg/kg, infuse, daily for 28 days) increases Nicotine infusions and shows an increased level of motivation to obtain Nicotine similarly in low responder and high responder rats than vehicle-treated rats[2].
Clorgyline hydrochloride (1mg/kg, i.v., pretreated for 1 h) pretreatment has little effect on the efflux of conjugated dopamine (DA) and p-tyramine-evoked release of conjugated DA from slices of rat striatum[3].
| [storage]
Store at -20°C | [References]
[1]. abdelhafez om, amin km, ali hi, et al. synthesis of new 7-oxycoumarin derivatives as potent and selective monoamine oxidase a inhibitors. j med chem. 2012 dec 13;55(23):10424-36.
[2]. mazouz f, gueddari s, burstein c, et al. 5-[4-(benzyloxy)phenyl]-1,3,4-oxadiazol-2(3h)-one derivatives and related analogues: new reversible, highly potent, and selective monamine oxidase type b inhibitors. j med chem. 1993 apr 30;36(9):1157-67.
[3]. garcia-miralles m, ooi j, ferrari bardile c, et al. treatment with the mao-a inhibitor clorgyline elevates monoamine neurotransmitter levels and improves affective phenotypes in a mouse model of huntington disease. exp neurol. 2016 apr;278:4-10. |
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