| Identification | Back Directory | [Name]
Pyridostatin hydrochloride | [CAS]
1781882-65-2 | [Synonyms]
Pyridostatin HCl
RR-82 hydrochloride
Pyridostatin hydrochloride | [Molecular Formula]
C5H6ClNSn8 | [MOL File]
1781882-65-2.mol | [Molecular Weight]
1065.24 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 2 mg/mL, clear | [form ]
Solid | [color ]
White to off-white | [Water Solubility ]
Water: 50 mg/mL (64.19 mM) | [InChIKey]
VGHSATQVJCTKEF-UHFFFAOYSA-N | [SMILES]
NCCOc1cc(nc(c1)C(=O)Nc4nc5c(c(c4)OCCN)cccc5)C(=O)Nc2nc3c(c(c2)OCCN)cccc3 |
| Hazard Information | Back Directory | [Uses]
Pyridostatin hydrochloride has been used as a G-quadruplex (G4)-stabilizing ligand to check the effect of G4s on fork progression. It has also been used as a G4-stabilizing ligand to study the effect of G4 on apurinic/apyrimidinic endonuclease 1 (APE1) mediated Kirsten rat sarcoma virus (KRAS) expression in pancreatic ductal adenocarcinoma (PDAC) cell lines. | [Biological Activity]
Pyridostatin (RR82) hydrochloride is a highly selective G-quadruplex DNA stabilizer (Kd=490 nM). It promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. | [in vitro]
Pyridostatin (RR82) hydrochloride (10 μM; 48 hours) induces cell cycle arrest. It is a very selective G-quadruplex DNA-binding small molecule designed to form a complex with and stabilize G-quadruplex structure. | [target]
Kd: 490 nM (G-quadruplexe) | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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