| Identification | Back Directory | [Name]
Propanamide, N-(2,3-dihydro-4,6-dimethyl-1-pentyl-1H-indol-7-yl)-2,2-dimethyl- | [CAS]
178469-71-1 | [Synonyms]
Propanamide, N-(2,3-dihydro-4,6-dimethyl-1-pentyl-1H-indol-7-yl)-2,2-dimethyl- | [Molecular Formula]
C20H32N2O | [MOL File]
178469-71-1.mol | [Molecular Weight]
316.48 |
| Hazard Information | Back Directory | [Uses]
KY-455 is a novel inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT). KY-455 inhibita rabbit intestinal, hepatic, macrophage and adrenal ACAT with IC50 values of 0.4, 0.9, 2.9 and 4.1 μmol/L, respectively. | [References]
[1] Shohei Nakamura, et al. Hypolipidemic and antioxidant activity of the novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor KY-455 in rabbits and hamsters. Arzneimittelforschung. 2004;54(2):102-8. DOI:10.1055/s-0031-1296943 |
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