| Identification | Back Directory | [Name]
K-604 dihydrochloride | [CAS]
217094-32-1 | [Synonyms]
K-604 2HCl
K-604
(K604)
K-604 >=98% (HPLC)
K-604 dihydrochloride | [Molecular Formula]
C23H31ClN6OS3 | [MOL File]
217094-32-1.mol | [Molecular Weight]
539.17 |
| Hazard Information | Back Directory | [Uses]
K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor with an IC50 of 0.45±0.06 μM. | [Biological Activity]
K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor with IC50 of 0.45±0.06 μM. | [in vivo]
Using F1B hamsters, an animal model susceptible to diet-induced hyperlipidemia and atherosclerosis, the effects of K-604 dihydrochloride on aortic lesion areas and plasma cholesterol levels are assessed. | [target]
| ACAT-1 < span> 0.45 μM (IC 50 ) | ACAT-2 102.85 μM (IC 50 ) | | [IC 50]
ACAT-1: 0.45 μM (IC50); ACAT-2: 102.85 μM (IC50) | [storage]
Store at -20°C | [References]
[1] Ikenoya M, et al. A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels. Atherosclerosis. 2007 Apr;191(2):290-7. DOI:10.1016/j.atherosclerosis.2006.05.048
[2] Shibuya Y, et al. Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage. Neurobiol Aging. 2015 Jul;36(7):2248-2259. DOI:10.1016/j.neurobiolaging.2015.04.002 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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