| Identification | Back Directory | [Name]
LOU064 | [CAS]
1787294-07-8 | [Synonyms]
LOU064
LOU-064
REMIBRUTINIB
N-(3-{5-[2-(Acryloyl-methyl-amino)-ethoxy]-6-amino-pyrimidin-4-yl}-5-fluoro-2-methyl-phenyl)-4-cyclopropyl-2-fluoro-benzamide
Benzamide, N-[3-[6-amino-5-[2-[methyl(1-oxo-2-propen-1-yl)amino]ethoxy]-4-pyrimidinyl]-5-fluoro-2-methylphenyl]-4-cyclopropyl-2-fluoro- | [Molecular Formula]
C27H27F2N5O3 | [MDL Number]
MFCD32215329 | [MOL File]
1787294-07-8.mol | [Molecular Weight]
507.53 |
| Chemical Properties | Back Directory | [Boiling point ]
634.8±55.0 °C(Predicted) | [density ]
1.332±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 125 mg/mL (246.29 mM) | [form ]
Solid | [pka]
11.67±0.70(Predicted) | [color ]
White to off-white | [InChIKey]
CUABMPOJOBCXJI-UHFFFAOYSA-N | [SMILES]
C(NC1=CC(F)=CC(C2C(OCCN(C)C(=O)C=C)=C(N)N=CN=2)=C1C)(=O)C1=CC=C(C2CC2)C=C1F |
| Hazard Information | Back Directory | [Description]
Remibrutinib, is a potent and orally active bruton tyrosine kinase (BTK) inhibitor with an IC50 value of 1 nM. Remibrutinib inhibits BTK activity with an IC50 value of 0.023 μM in blood. Remibrutinib has the potential for Chronic urticaria (CU) treatment. | [Chemical Properties]
White to off-white Solid | [Uses]
Remibrutinib, is a potent and orally active bruton tyrosine kinase (BTK) inhibitor with an IC50 value of 1 nM. Remibrutinib inhibits BTK activity with an IC50 value of 0.023 μM in blood[1]. Remibrutinib has the potential for Chronic urticaria (CU) treatment[2]. | [References]
[1] Daniela Angst, et al. Novel amino pyrimidine derivatives. Patent WO2015079417A1.
[2] Kolkhir P, et al. New treatments for chronic urticaria. Ann Allergy Asthma Immunol. 2019 Aug 23. DOI:10.1016/j.anai.2019.08.014 |
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