| Identification | Back Directory | [Name]
Delta3,2-Hydroxylbakuchiol | [CAS]
178765-49-6 | [Synonyms]
13-Hydroxyisobakuchiol
Delta3,2-Hydroxylbakuchiol
Delta3,2-Hydroxylbakuchiol/13-Hydroxyisobakuchiol
4-[(1E,3S,5E)-3-Ethenyl-7-hydroxy-3,7-dimethyl-1,5-octadienyl]phenol
Phenol, 4-[(1E,3S,5E)-3-ethenyl-7-hydroxy-3,7-dimethyl-1,5-octadienyl]- | [Molecular Formula]
C18H24O2 | [MDL Number]
MFCD32000979 | [MOL File]
178765-49-6.mol | [Molecular Weight]
272.38 |
| Hazard Information | Back Directory | [Uses]
Hydroxyisobakuchiol (Delta3,2-Hydroxylbakuchiol), an analog of Bakuchiol (HY-N0235) isolated from Psoralea corylifolia (L.), is a potent monoamine transporter inhibitor. 13-Hydroxyisobakuchiol is more selective for the dopamine transporter (DAT) (IC50=0.58 μM) and norepinephrine transporter (NET) (IC50=0.69 μM) than for the serotonin transporter (SERT) (IC50=312.02 μM). 13-Hydroxyisobakuchiol has the potential for the research of disorders such as Parkinson's disease and depression[1]. | [References]
[1] Gang Zhao, et al. Bakuchiol analogs inhibit monoamine transporters and regulate monoaminergic functions. Biochem Pharmacol. 2008 May 1;75(9):1835-47. DOI:10.1016/j.bcp.2008.01.014 |
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