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179343-17-0

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179343-17-0 Structure

179343-17-0 Structure
IdentificationBack Directory
[Name]

PD089828
[CAS]

179343-17-0
[Synonyms]

PD089828
1-(2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-(tert-butyl)urea
Urea, N-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-
[Molecular Formula]

C18H18Cl2N6O
[MOL File]

179343-17-0.mol
[Molecular Weight]

405.28
Chemical PropertiesBack Directory
[density ]

1.416±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 25 mg/ml; Ethanol: 1 mg/ml
[form ]

A solid
[pka]

9.85±0.43(Predicted)
[color ]

White to light yellow
Hazard InformationBack Directory
[Uses]

PD 089828 is an ATP competitive inhibitor of the growth factor receptor tyrosine kinases FGFR-1, PDGFR-beta and EGFR.
[IC 50]

FGFR1: 0.15 μM (IC50); PDGFR-β: 1.76 μM (IC50); EGFR: 5.47 μM (IC50); c-Src: 0.18 μM (IC50); FGFR1: 0.14 μM (Ki); PDGFR-β: 2.38 μM (Ki); EGFR: 3.16 μM (Ki); c-Src: 0.1 μM (Ki)
Spectrum DetailBack Directory
[Spectrum Detail]

PD089828(179343-17-0)1HNMR
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