| Identification | Back Directory | [Name]
MIK665 | [CAS]
1799631-75-6 | [Synonyms]
MIK665
S64315
MIK665,S64315
S64315 (MIK665)
MIK665 (S-64315, MIK-665)
(2S)-2-(5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yloxy)-3-(2-((2-(2-methoxyphenyl)pyrimidin-4-yl)methoxy)phenyl)propanoic acid
Benzenepropanoic acid, α-[[(5S)-5-[3-chloro-2-methyl-4-[2-(4-methyl-1-piperazinyl)ethoxy]phenyl]-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy]-2-[[2-(2-methoxyphenyl)-4-pyrimidinyl]methoxy]-, (αR)- | [Molecular Formula]
C47H44ClFN6O6S | [MOL File]
1799631-75-6.mol | [Molecular Weight]
875.41 |
| Chemical Properties | Back Directory | [Boiling point ]
909.4±65.0 °C(Predicted) | [density ]
1.324±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: soluble | [form ]
A solid | [pka]
2.53±0.11(Predicted) | [color ]
White to off-white | [InChIKey]
PKYIMGFMRFVOMB-UHFFFAOYSA-N | [SMILES]
O(C1N=CN=C2SC(C3C=CC(F)=CC=3)=C(C3C=CC(OCCN4CCN(C)CC4)=C(Cl)C=3C)C=12)C(C(=O)O)CC1C=CC=CC=1OCC1C=CN=C(C2C=CC=CC=2OC)N=1 |
| Hazard Information | Back Directory | [Uses]
MIK665 (S-64315), derived from S63845, is a myeloid cell leukemia sequence 1 (MCL1) inhibitor[1]. MIK665 has an IC50 of 1.81 nM for MCL1[2]. | [IC 50]
Mcl-1: 1.81 nM (IC50) | [References]
[1] Mukherjee N, et al. Simultaneously Inhibiting BCL2 and MCL1 Is a Therapeutic Option for Patients with Advanced Melanoma. Cancers (Basel). 2020;12(8):2182. Published 2020 Aug 5. DOI:10.3390/cancers12082182
[2] Zoltán SZLáVIK, et al. New hydroxyester derivatives, a process for their preparation and pharmaceutical compositions containing them. WO2016207225A1. |
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| Company Name: |
Elucigen bio Gold
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| Tel: |
13501719342; 13501719342 |
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