ChemicalBook--->CAS DataBase List--->180288-69-1

180288-69-1

180288-69-1 Structure

180288-69-1 Structure
IdentificationBack Directory
[Name]

Trastuzumab
[CAS]

180288-69-1
[Synonyms]

Herceptin
RhuMab HER2
Trastuzumab Beta
TRASTUZUMAB 95 % +
TRASTUZUMAB 98 % +
Trastuzumab USP/EP/BP
TrastuzuMab(Herceptin)
Trastuzumab (anti-HER2)
Trastuzumab,Stock solution
Trastuzumab - 20mg/ml in PBS
Anti HER2, Ig gamma-1 chain C region
Recombinant humanized anti-HER2 antibody
IMMunoglobulin G1,anti-(huMan p185neu receptor) (huMan-Mouse Monoclonal rhuMab HER2 g1-chain), disulfide with huMan-MouseMonoclonal rhuMab HER2 light chain, diMer
[Molecular Formula]

C10H14N6O5
[MDL Number]

MFCD03702625
[MOL File]

180288-69-1.mol
[Molecular Weight]

298.255
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
Safety DataBack Directory
[Symbol(GHS) ]


GHS08
[Signal word ]

Danger
[Hazard statements ]

H360
[Hazardous Substances Data]

180288-69-1(Hazardous Substances Data)
Hazard InformationBack Directory
[Indications]

The introduction of herceptin (Trastuzumab) into clinical practice for the treatment of breast cancer marks a major advance in the use of monoclonal antibody cancer therapy. Herceptin is a humanized antibody directed against the HER-2 antigen that is overexpressed on the tumor cell surface in approximately 25% of breast cancer patients. HER-2/neu/erbB2 overexpression marks an aggressive estrogen receptor–negative form of breast cancer. Therefore, a therapeutic agent selective for this target is particularly valuable. Herceptin is administered by intravenous infusion and in conjunction with paclitaxel can extend survival in patients with HER-2/neu/erbB2 overexpressing metastatic breast cancer.Herceptin use is associated with infusion- related hypotension, flushing and bronchoconstriction, and skin rash but no bone marrow toxicity. Herceptin appears to sensitize patients to cardiotoxicity, an important concern in patients also receiving doxorubicin.
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