| Identification | Back Directory | [Name]
Bromazine Hydrochloride | [CAS]
1808-12-4 | [Synonyms]
deserol
bromazin
Bromazine HCl
bromo-benzdryl
EINECS 204-238-8
ambodrylhydrochloride
bromazine hydrochloride
Bromodiphenhydramine HCl
bromodiphenhydraminehydrochloride
Diphenhydramine EP Impurity C HCl
bromdiphenylhydraminehydrochloride
Diphenhydramine Impurity C hydrochloride
Dimenhydrinate Impurity H as Hydrochloride
Bromodiphenhydramine Hydrochloride (1077005)
2-(4-bromodiphenylmethoxy)ethyldimethylamine
Dimenhydrinate EP Impurity H as Hydrochloride
BROMODIPHENHYDRAMINE HYDROCHLORIDE (200 MG)
4-bromo-alpha-phenylbenzyl2-dimethylaminoethylether
Diphenhydramine Impurity C HCl (Bromazine Hydrochloride)
Diphenhydramine Impurity 3（Diphenhydramine EP Impurity C）
Diphenhydramine Hydrochloride Impurity C as Hydrochloride
2-(4-BroModiphenylMethoxy)ethyldiMethylaMine Hydrochloride
2-(4-bromobenzohydryloxy)-ethyl-dimethylaminehydrochloride
beta-(p-bromobenzhydryloxy)ethyldimethylaminehydrochloride
Diphenhydramine Hydrochloride EP Impurity C as Hydrochloride
2-[(4-bromophenyl)phenylmethoxy]ethyl(dimethyl)ammonium chloride
2-((4-bromophenyl)phenylmethoxy)-n,n-dimethyl-ethanaminhydrochloride
2-[(p-BroMo-α-phenylbenzyl)oxy]-N,N-diMethylethylaMine Hydrochloride
2-[(4-BroMophenyl)phenylMethoxy]-N,N-diMethylethanaMine Hydrochloride
2-((p-bromo-alpha-phenylbenzyl)oxy)-n,n-dimethylethylaminehydrochloride
2-((p-bromo-alpha-phenylbenzyl)oxy)-n,n-dimethyl-ethylaminhydrochloride
IMp. H (EP) as Hydrochloride: 2-[(RS)-(4- BroMophenyl)(phenyl)Methoxy]-N,N-diMethyl- ethanaMine Hydrochloride (4-BroModiphen- hydraMine Hydrochloride | [EINECS(EC#)]
217-310-9 | [Molecular Formula]
C17H21BrClNO | [MDL Number]
MFCD01727165 | [MOL File]
1808-12-4.mol | [Molecular Weight]
370.712 |
| Chemical Properties | Back Directory | [Melting point ]
144-145° | [storage temp. ]
Refrigerator | [solubility ]
Acetone (Slightly), Methanol (Slightly), Water (Slightly) | [form ]
Solid | [color ]
Pale Yellow | [BRN ]
3754363 | [Major Application]
pharmaceutical (small molecule) | [InChI]
InChI=1S/C17H20BrNO.ClH/c1-19(2)12-13-20-17(14-6-4-3-5-7-14)15-8-10-16(18)11-9-15;/h3-11,17H,12-13H2,1-2H3;1H | [InChIKey]
ZQDJSWUEGOYDGT-UHFFFAOYSA-N | [SMILES]
C(OCCN(C)C)(C1=CC=CC=C1)C1=CC=C(Br)C=C1.Cl |
| Safety Data | Back Directory | [WGK Germany ]
WGK 1 | [HS Code ]
2922190900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral |
| Hazard Information | Back Directory | [Description]
Bromodiphenhydramine is a histamine H1 receptor antagonist. It induces histamine release in isolated guinea pig lung when used at a concentration of 1 mM but completely prevents ovalbumin-induced histamine release in lungs isolated from ovalbumin-sensitized guinea pigs when used at concentrations of 100 and 200 μg/ml. Bromodiphenhydramine (17 mg/kg) inhibits formalin-induced paw edema in rats. It increases survival in a mouse model of systemic S. typhimurium infection when administered at doses of 1.5 and 3 mg/kg. | [Uses]
Antihistaminic. | [Definition]
ChEBI: The hydrochloride salt of bromazine. An antihistamine with antimicrobial properties, it is used in the control of cutaneous allergies. | [Brand name]
Ambodryl. | [General Description]
Bromodiphenhydraminehydrochloride, 2-[(4-bromophenyl)-phenylmethoxy]-N, N-dimethylethanamine hydrochloride(Ambodryl Hydrochloride), is a white to pale buff crystallinepowder that is freely soluble in water and in alcohol.Relative to diphenhydramine, bromodiphenhydramine ismore lipid soluble and was twice as effective in protectingagainst the lethal effects of histamine aerosols. | [References]
[1] ABBAS AHMADI. Synthesis and anti-inflammatory effects of new piperazine and ethanolamine derivatives of H(1)-antihistaminic drugs.[J]. Mini reviews in medicinal chemistry, 2012, 12 12: 1282-1292. DOI: 10.2174/138955712802762013
[2] I. MOTA W. D D S. THE ANTI-ANAPHYLACTIC AND HISTAMINE-RELEASING PROPERTIES OF THE ANTIHISTAMINES. THEIR EFFECT ON THE MAST CELLS[J]. British Journal of Pharmacology, 1960, 15 3: 396-404. DOI: 10.1111/j.1476-5381.1960.tb01262.x
[3] SUJATA G. DASTIDAR. Antibacterial Activity of Ambodryl and Benadryl[J]. Journal of Applied Microbiology, 1976, 41 2: 209-214. DOI: 10.1111/j.1365-2672.1976.tb00621.x |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
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