| Identification | More | [Name]
1-(4-Bromophenyl)ethanol | [CAS]
5391-88-8 | [Synonyms]
1-(4'-BROMOPHENYL)-1-HYDROXYETHANE
1-(4-BROMOPHENYL)ETHANOL
1-(4-BROMOPHENYL)ETHYL ALCOHOL
4-BROMO-ALPHA-METHYLBENZYL ALCOHOL
4-BROMO-A-METHYLBENZYL ALCOHOL
4-BROMOPHENYL METHYL CARBINOL
AURORA KA-6987
P-BROMOPHENYLMETHYLCARBINOL
4-Bromo-alpha-methylbenzenemethanol
Benzyl alcohol, p-bromo-alpha-methyl-
p-Bromo-alpha-methylbenzyl alcohol
4-Bromo-alpha-methylbenzyl alcohol~4-Bromophenyl methyl carbinol
4-bromo-à-methylbenzyl alcohol
Benzenemethanol, 4-bromo-alpha-methyl-
1-(p-Bromophenyl)ethyl alcohol
4-Bromo-α-methylbenzenemethanol
α-Methyl-4-bromobenzenemethanol
α-Methyl-4-bromobenzyl alcohol | [EINECS(EC#)]
226-389-9 | [Molecular Formula]
C8H9BrO | [MDL Number]
MFCD00004514 | [Molecular Weight]
201.06 | [MOL File]
5391-88-8.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light brown crystalline powder | [Melting point ]
36-38 °C(lit.) | [Boiling point ]
119-121 °C7 mm Hg(lit.) | [density ]
1.46 g/mL at 25 °C(lit.)
| [refractive index ]
1.5680 | [Fp ]
146 °F
| [storage temp. ]
Store at room temperature | [form ]
Crystalline Powder | [pka]
14.22±0.20(Predicted) | [color ]
White to light brown | [Specific Gravity]
1.460 | [BRN ]
2042029 | [InChI]
1S/C8H9BrO/c1-6(10)7-2-4-8(9)5-3-7/h2-6,10H,1H3 | [InChIKey]
XTDTYSBVMBQIBT-UHFFFAOYSA-N | [SMILES]
CC(O)c1ccc(Br)cc1 | [CAS DataBase Reference]
5391-88-8(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzenemethanol, 4-bromo-«alpha»-methyl-(5391-88-8) |
| Questions And Answer | Back Directory | [Synthesis]
There are many ways to prepare 1-(4-Bromophenyl)ethanol. It can be prepared by reducing 1-(4-bromophenyl)-1-ethyl ketone or 1-(4-bromophenyl)-1-acetic acid with sodium borohydride; or by reacting p-bromobenzyl chloride with sodium acetate in glacial acetic acid to produce p-bromobenzyl acetate, and then by alkaline hydrolysis of p-bromobenzyl acetate to obtain 1-(4-Bromophenyl)ethanol. In this paper, p-bromobenzaldehyde is used as the starting material, and 1-(4-Bromophenyl)ethanol is prepared by reacting it with chloroform with dimethylformamide (DMF) as solvent under the catalysis of potassium hydroxide/methanol. The reaction conditions of this process route are optimized [1]. The synthetic reaction formula for 1-(4-Bromophenyl)ethanol is shown in the figure below: 
|
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [HS Code ]
29062900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
white to light brown crystalline powder | [Uses]
4-Bromo-α-methylbenzyl alcohol was used in the synthesis of 3-(4-(1-(tert-butyl)dimethylsilyloxy)ethyl)phenyl)-3-(trifluoromethyl)-3H-diazirine and (1-(4-bromophenyl)ethoxy)(tert-butyl)dimethylsilane. | [Purification Methods]
The (±)-racemate is purified by distillation in a vacuum (b 90o/1mm, 119-121o/7mm, d 1.46) and it solidifies on cooling (m 36-37o) [Overberger et al. Org Synth |
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