| Identification | Back Directory | [Name]
2-HYDROXYADENOSINE | [CAS]
1818-71-9 | [Synonyms]
iso-Gr
NSC 12161
CROTONOSID
CROTONOSIDE
ISOGUANOSINE
ISOGUANOSINE(P)
2-Hydroxydenosine
isoguanineriboside
2-HYDROXYADENOSINE
2(1H)-Oxoadenosine
Adenosine Impurity 6
ISOGUANOSINE RIBOSIDE
Regadenoson Impurity 17
Crotonoside >=95% (HPLC)
1,2-dihydro-2-oxo-adenosin
1,2-dihydro-2-oxoadenosine
2,3-dihydro-2-oxo-Adenosine
Adenosine, 2,3-dihydro-2-oxo-
9-(β-D-Ribofuranosyl)isoguanine
9-(b-D-Ribofuranosyl)isoguanine
Crotonoside, 98%, from Croton tiglium L.
6-amino-9-beta-d-ribofuranosyl-9h-purin-2-o
6-Amino-9-β-D-ribofuranosyl-9H-purin-2(1H)-one
2-?Hydroxyadenosine
DISCONTINUED. Please see I819500
6-amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,9-dihydro-2H-purin-2-one | [Molecular Formula]
C10H13N5O5 | [MDL Number]
MFCD04971989 | [MOL File]
1818-71-9.mol | [Molecular Weight]
283.24 |
| Chemical Properties | Back Directory | [Melting point ]
237-241 °C(Solv: water (7732-18-5)) | [density ]
2.25±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
powder | [pka]
8.25±0.40(Predicted) | [color ]
White to off-white | [Major Application]
metabolomics
vitamins, nutraceuticals, and natural products | [InChI]
1S/C10H13N5O5/c11-7-4-8(14-10(19)13-7)15(2-12-4)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1 | [InChIKey]
MIKUYHXYGGJMLM-UUOKFMHZSA-N | [SMILES]
NC1=NC(NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)=O |
| Hazard Information | Back Directory | [Description]
Crotonoside is a purine analogue that is structurally similar to pyrazole, which also inhibits the polymerase chain reaction in vitro. Crotonoside has been shown to be an inhibitor of the polymerase chain reaction in vitro, but it is unclear if this activity will translate to in vivo models. | [Chemical Properties]
White crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the fruit of Croton tiglium L. | [Uses]
2-?Hydroxyadenosine is an isoquinoline alkaloid displaying anticancer activity. | [Definition]
ChEBI: Crotonoside is a purine nucleoside. | [in vivo]
Crotonoside(intraperitoneal and intravenous injection; 70 mg/kg, 35 mg/kg; once daily) induces a significant antitumor activity and inhibited xenograft tumor progress as compared to treatment with vehicle[1]. | Animal Model: | NOD-SCID mice with MV4-11 cells[1] | | Dosage: | 70 mg/kg, 35 mg/kg | | Administration: | Intraperitoneal and intravenous injection; 70 mg/kg, 35 mg/kg; once daily | | Result: | Produced significant AML tumor inhibition rates of 93.5% at 70 mg/kg. |
| [target]
Adenosine Receptor | [IC 50]
FLT3; HDAC3; HDAC6 |
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