| Identification | Back Directory | [Name]
CB1151 | [CAS]
182369-28-4 | [Synonyms]
CB1151
1,3-Cyclohexanediol, 5-[(2E)-[(1S,3aS,7aS)-1-[(1R)-1-[(3-ethyl-3-hydroxypentyl)oxy]ethyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1R,3S,5Z)- (9CI) | [Molecular Formula]
C28H46O4 | [MDL Number]
MFCD30207820 | [MOL File]
182369-28-4.mol | [Molecular Weight]
446.66 |
| Chemical Properties | Back Directory | [Boiling point ]
601.5±55.0 °C(Predicted) | [density ]
1.07±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light, stored under nitrogen | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
14.43±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
CB1151 is a 20-epi analogue of 1,25 dihydroxyvitamin D3 (VD) with potent anti-tumor effects. CB1151 inhibits MCF-7 cell growth with an IC50 value of 0.82 nM[1]. | [References]
[1] M?rk Hansen C, et al. The potent anti-proliferative effect of 20-epi analogues of 1,25 dihydroxyvitamin D3 in human breast-cancer MCF-7 cells is related to promoter selectivity.Int J Cancer. 1996 Sep 4;67(5):739-42. DOI:10.1002/(SICI)1097-0215(19960904)67:53.0.CO;2-Z
[2] Nayeri S, et al. High-affinity nuclear receptor binding of 20-epi analogues of 1,25-dihydroxyvitamin D3 correlates well with gene activation.J Cell Biochem. 1996 Sep 1;62(3):325-33. DOI:10.1002/(SICI)1097-4644(199609)62:3%3C325::AID-JCB3%3E3.0.CO;2-T |
|
| Company Name: |
MedChemExpress
|
| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
|