| Identification | Back Directory | [Name]
9-Octadecenoic acid, 2-hydroxy-, (2R,9Z)- | [CAS]
182370-45-2 | [Synonyms]
(R)-2-OHOA
Idroxioleic acid
(R)-2-Hydroxyoleic acid
9-Octadecenoic acid, 2-hydroxy-, (2R,9Z)- | [Molecular Formula]
C18H34O3 | [MOL File]
182370-45-2.mol | [Molecular Weight]
298.46 |
| Hazard Information | Back Directory | [Uses]
Idroxioleic acid ((R)-2-Hydroxyoleic acid; (R)-2-OHOA), the R enantiomer of (Rac)-Idroxioleic acid, is an orally active fatty acid that modulates the lipid composition and structure of the membranes. Idroxioleic acid has antitumor activities[1]. | [in vivo]
Idroxioleic acid ((R)-2-Hydroxyoleic acid; (R)-2-OHOA; 400 mg/kg; p.o.; daily; for 21 days) causes a reduction in tumor volume of about 20-25% after 21 days[1]. | Animal Model: | Male NUDE (Swiss) Crl:NU(Ico)-Foxn1nu mice (5 weeks old, 30-35 g) injected with A549 human lung cancer cells[1] | | Dosage: | 400 mg/kg | | Administration: | p.o.; daily; for 21 days | | Result: | Caused a reduction in tumor volume of about 20-25% after 21 days. |
| [References]
[1] Stefano Piotto, et al. Differential effect of 2-hydroxyoleic acid enantiomers on protein (sphingomyelin synthase) and lipid (membrane) targets. Biochim Biophys Acta. 2014 Jun;1838(6):1628-37. DOI:10.1016/j.bbamem.2013.12.023 |
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