| Identification | Back Directory | [Name]
Y06036 | [CAS]
1832671-96-1 | [Synonyms]
Y06036
Benzenesulfonamide, 5-bromo-2-methoxy-N-(6-methoxy-3-methyl-1,2-benzisoxazol-5-yl)- | [Molecular Formula]
C16H15BrN2O5S | [MDL Number]
MFCD31813647 | [MOL File]
1832671-96-1.mol | [Molecular Weight]
427.27 |
| Hazard Information | Back Directory | [Uses]
Y06036 is CRPC inhibitor. | [in vivo]
Y06036 (50 mg/kg, i.p. injection, 5 times per week, 25 days) demonstrates therapeutic effects in a C4-2B CRPC xenograft tumor model in mice. Y06036 is well tolerated in the treated mice, based on the weight of the animal body and their general behavior[1]. | Animal Model: | Four-week-old male mice (strain: C.B-17/IcrHsd-Prkdcscid for C4-2B) with C4-2B mouse xenograft model[1] | | Dosage: | 50 mg/kg, 100 μL | | Administration: | Intraperitoneal (i.p.) injection, 5 times per week, 25 days | | Result: | Exhibited strong antitumor activities during the 25-day treatment period, with a tumor growth inhibition (TGI) of 70%. |
| [IC 50]
BRD4(1): 82 nM (Kd) |
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| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 13348960310 |
| Website: |
www.weikeqi-biotech.com/ |
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