| Identification | More | [Name]
4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline | [CAS]
183322-18-1 | [Synonyms]
4-chloro-6,7-bis(2-methoxyethoxy)quinazoline
4-Chloro-6,7-(2-methoxyethoxy)quinazoline
4-Chloro-6,7-bis(2-methoxyethoxy)quinazolin
6,7-Bis(2-methoxyethoxy)-4-chloroquinazoline | [EINECS(EC#)]
605-994-5 | [Molecular Formula]
C14H17ClN2O4 | [MDL Number]
MFCD09751265 | [Molecular Weight]
312.75 | [MOL File]
183322-18-1.mol |
| Questions And Answer | Back Directory | [Synthesis]
The 4-quinazolinone analogue (8.0 mmol) was refluxed in a mixture of 27.4 mL sulfoxide containing N,N-dimethylformamide (2 drops) for 8 hours. After the reaction was complete, unreacted sulfoxide was removed under reduced pressure. The residue obtained by rotary evaporation was dissolved in dichloromethane. The solution was washed with saturated aqueous sodium bicarbonate solution and brine. The mixture was dried over anhydrous sodium sulfate. The mixture was concentrated under reduced pressure to give the product. Synthetic route from phosphine oxychloride: 40.8 g of 6,7-bis(2-methoxyethoxy)quinazolin-4(3H)-one, 25.5 g (167 mmol), and triethylamine (33.7 g (334 mmol)) were added to a three-necked flask, followed by toluene. The resulting mixture was stirred at 70–80 °C for 3 hours. After the reaction was complete, excess POCl3 was removed by rotary evaporation. Note that the material must not come into contact with water during post-processing, otherwise it may easily deteriorate.
|
| Chemical Properties | Back Directory | [Melting point ]
105-107 °C | [Boiling point ]
446.7±45.0 °C(Predicted) | [density ]
1.257 | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
DMSO: ≥20mg/mL | [form ]
powder | [pka]
0.54±0.30(Predicted) | [color ]
white to off-white | [InChI]
InChI=1S/C14H17ClN2O4/c1-18-3-5-20-12-7-10-11(16-9-17-14(10)15)8-13(12)21-6-4-19-2/h7-9H,3-6H2,1-2H3 | [InChIKey]
ZPJLDMNVDPGZIU-UHFFFAOYSA-N | [SMILES]
N1=C2C(C=C(OCCOC)C(OCCOC)=C2)=C(Cl)N=C1 | [CAS DataBase Reference]
183322-18-1(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Uses]
4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline is an aurora 2 kinase inhibitor, PDGF inhibitor, useful in the treatment of cancer.
| [Biological Activity]
CP-335963 is an aurora 2 kinase inhibitorPDGF inhibitorand anti-proliferative. | [storage]
Store at -20°C |
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