1835-11-6

100-39-0

498-02-2

1835-11-6

The general procedure for the synthesis of 4-benzyloxy-3-methoxyacetophenone from benzyl bromide and vanillylacetophenone was as follows: 4-hydroxy-3-methoxyacetophenone (40 g, 240 mmol), benzyl bromide (31.4 mL, 260 mmol), and potassium carbonate (99.6 g, 360 mmol) were dissolved in N,N-dimethylformamide (DMF, 800 mL) and the reaction The mixture was heated to 40 °C and stirred overnight. After completion of the reaction, the mixture was cooled to room temperature, poured into ice water and the solid product precipitated was collected by filtration. The solid product was washed with water and dried to give 1-(4-benzyloxy-3-methoxyphenyl)ethanone (61 g, 99% yield).