| Identification | Back Directory | [Name]
Acid-PEG3-PFP ester | [CAS]
1835759-67-5 | [Synonyms]
Acid-PEG3-PFP ester
Propanoic acid, 3-[2-[2-(2-carboxyethoxy)ethoxy]ethoxy]-, 1-(2,3,4,5,6-pentafluorophenyl) ester | [Molecular Formula]
C16H17F5O7 | [MDL Number]
MFCD29052176 | [MOL File]
1835759-67-5.mol | [Molecular Weight]
416.29 |
| Hazard Information | Back Directory | [Description]
Acid-PEG3-PFP ester is a PEG linker containing a carboxylic acid and PFP ester end group. The carboxylic acid can react with amines in the presence of activators such as EDC and HATU to form a stable amide bond. The PFP ester can also react with amine groups. The hydrophilic PEG chains increase the water solubility of the compound in aqueous media. | [Uses]
Acid-PEG3-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
|
|