| Identification | Back Directory | [Name]
Acid-PEG3-t-butyl ester | [CAS]
1807539-06-5 | [Synonyms]
COOH-PEG3-OtBu
COOH-PEG3-COOtBu
Acid-PEG3-C2-Boc
Acid-PEG3-t-butyl ester
HOOCCH2CH2O-PEG2-CH2CH2COOtBu
2,2-Dimethyl-4-oxo-3,7,10,13-tetraoxahexadecan-16-oic acid
4,7,10,14-Tetraoxahexadecanoic acid, 15,15-dimethyl-13-oxo- | [Molecular Formula]
C14H26O7 | [MDL Number]
MFCD28015771 | [MOL File]
1807539-06-5.mol | [Molecular Weight]
306.35 |
| Chemical Properties | Back Directory | [Boiling point ]
423.2±35.0 °C(Predicted) | [density ]
1.106±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
Liquid | [pka]
4.28±0.10(Predicted) | [color ]
Colorless to light yellow | [InChI]
InChI=1S/C14H26O7/c1-14(2,3)21-13(17)5-7-19-9-11-20-10-8-18-6-4-12(15)16/h4-11H2,1-3H3,(H,15,16) | [InChIKey]
VDWZJPCGUNJFEE-UHFFFAOYSA-N | [SMILES]
C(O)(=O)CCOCCOCCOCCC(=O)OC(C)(C)C |
| Hazard Information | Back Directory | [Description]
Acid-PEG3-t-butyl ester is a PEG linker containing a t-butyl protected carboxyl group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Acid-PEG3-C2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs for the degradation of EGFR and inhibition of mTOR[1][2]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] Nathanael Gray, et al. Bifunctional molecules for degradation of egfr and methods of use. WO2017185036A1.
[2] Christopher Semko, et al. Rapamycin analogs as mtor inhibitors. WO 2018204416 A1. |
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