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1835759-75-5

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1835759-75-5 Structure

1835759-75-5 Structure
IdentificationBack Directory
[MDL Number]

MFCD29052203
Chemical PropertiesBack Directory
[Boiling point ]

528.4±60.0 °C(Predicted)
[density ]

1.21±0.1 g/cm3(Predicted)
[form ]

Viscous Liquid
[color ]

Colorless to light yellow
Hazard InformationBack Directory
[Description]

t-Butoxycarbonyl-PEG4-NHS ester has a t-Boc protecting group and an NHS ester moiety. The t-butyl group can be deprotected under acidic conditions. NHS ester can react specifically and efficiently with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic condition to form a covalent bond. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.
[Uses]

Boc-PEG4-C2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
[IC 50]

PEGs
[References]

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Spectrum DetailBack Directory
[Spectrum Detail]

t-Butoxycarbonyl-PEG4-NHS ester(1835759-75-5)1HNMR
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