| Identification | Back Directory | [Name]
CYN 154806 | [CAS]
183658-72-2 | [Synonyms]
CYN 154806
CYANAMID 154806
CYN 154806; CYN154806
M.W. 1197.35 C56H68N12O14S2
CYN 154806 TRIFLUOROACETATE SALT
CYANAMID 154806 trifluoroacetate salt
AC-(4-NITRO)PHE-D-CYS-TYR-D-TRP-LYS-THR-CYS-D-TYR-NH2
D-Tyrosinamide, N-acetyl-4-nitro-L-phenylalanyl-D-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic (2→7)-disulfide | [Molecular Formula]
C56H68N12O14S2 | [MDL Number]
MFCD06411598 | [MOL File]
183658-72-2.mol | [Molecular Weight]
1197.34 |
| Chemical Properties | Back Directory | [Boiling point ]
1656.2±65.0 °C(Predicted) | [density ]
1.47±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
H2OPeptide Solubility and Storage Guidelines:1.??Calculate the length of the peptide.2.??Calculate the overall charge of the entire peptide according to the following table:3.??Recommended solution: | [form ]
powder
| [pka]
9.87±0.15(Predicted) | [color ]
white to off-white
| [Water Solubility ]
Soluble to 1 mg/ml in water | [Sequence]
Ac-{L-4-NO2-Phe}{D-CYS}-Tyr-{D-TRP}-Lys-Thr-Cys{D-TYR}-NH2 (Disulfidebridge:Cys2-Cys7) |
| Hazard Information | Back Directory | [Description]
CYN 154806 is a cyclic peptide somatostatin receptor 2 (SST2) antagonist (IC50 = 2.62 nM).1 It is selective for SST2 over SST1, SST3, SST4, and SST5 (IC50s = 3,890, 851, 1,737, and 331 nM, respectively). CYN 154806 inhibits SST-induced increases in extracellular acidification (EAR) in CHO-K1 cells expressing recombinant human SST2 (pKB = 7.92) and [35S]GTPγS binding in CHO-K1 cell membranes expressing recombinant human SST2 (pKB = 7.81).WARNING This product is not for human or veterinary use. | [Biochem/physiol Actions]
Potent and selective sst2 somatostatin receptor antagonist. | [storage]
Desiccate at -20°C | [References]
[1] W FENIUK. Selective somatostatin sst2 receptor blockade with the novel cyclic octapeptide, CYN-154806[J]. Neuropharmacology, 2000, 39 8: Pages 1443-1450. DOI: 10.1016/s0028-3908(00)00035-6 |
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Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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BOC Sciences
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https://www.bocsci.com |
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