| Identification | More | [Name]
1,2,3,4,5,6-HEXABROMOCYCLOHEXANE | [CAS]
1837-91-8 | [Synonyms]
NSC 7908
JAK2 INHIBITOR II
BENZENE HEXABROMIDE
trans-α-Benzene hexabromide
1,2,3,4,5,6-Hexabromcyclohexan
1,2,3,4,5,6-hexabromo-cyclohexan
1,2,3,4,5,6-HEXABROMOCYCLOHEXANE
Cyclohexane, 1,2,3,4,5,6-hexabromo-
JAK2 Inhibitor II - CAS 1837-91-8 - Calbiochem | [Molecular Formula]
C6H6Br6 | [MDL Number]
MFCD00059127 | [Molecular Weight]
557.54 | [MOL File]
1837-91-8.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
3 | [TSCA ]
Yes |
| Hazard Information | Back Directory | [Uses]
1,2,3,4,5,6-Hexabromocyclohexane is a potent and specific inhibitor of JAK2 autophosphorylation. | [Definition]
ChEBI: 1,2,3,4,5,6-hexabromocyclohexane is a bromohydrocarbon that is cyclohexane in which the hydrogen at positions 1,2,3,4,5 and 6 have been replaced by bromo groups. It is a potent inhibitor of JAK2 tyrosine kinase autophosphorylation. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a bromohydrocarbon and a bromoalkane. It derives from a hydride of a cyclohexane. | [Biological Activity]
Potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation. A 16-hour treatment with 1 μ M of compound reduces JAK2 tyrosine autophosphorylation levels to ~ 50% while 50 μ M elimates nearly all JAK2 activity. Non-cytotoxic at 100 μ M. | [storage]
Store at RT |
| Spectrum Detail | Back Directory | [Spectrum Detail]
1,2,3,4,5,6-HEXABROMOCYCLOHEXANE(1837-91-8)MS
1,2,3,4,5,6-HEXABROMOCYCLOHEXANE(1837-91-8)IR1
1,2,3,4,5,6-HEXABROMOCYCLOHEXANE(1837-91-8)IR2
1,2,3,4,5,6-HEXABROMOCYCLOHEXANE(1837-91-8)Raman
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