| Identification | Back Directory | [Name]
c(phg-isoDGR-(NMe)k) | [CAS]
1844830-65-4 | [Synonyms]
c(phg-isoDGR-(NMe)k)
Cyclo(Arg-NMe-DLys-DPhg-β-Asp-Gly)
c(phgisoDGR(NMe)k),c(phg isoDGR (NMe)k)
Cyclo[L-arginyl-N2-methyl-D-lysyl-(2R)-2-phenylglycyl-L-β-aspartylglycyl] | [Molecular Formula]
C27H41N9O7 | [MOL File]
1844830-65-4.mol | [Molecular Weight]
603.68 |
| Hazard Information | Back Directory | [Uses]
c(phg-isoDGR-(NMe)k) is a selective and potent α5β1-integrin ligand with an IC50 of 2.9 nM[1]. | [in vivo]
c(phg-isoDGR-(NMe)k) is trimerized with the chelator TRAP and used as a positron-emission tomography tracer for monitoring α5β1 integrin expression in a M21 mouse xenograft[1]. | [References]
[1] Kapp TG, et al. N-Methylation of isoDGR Peptides: Discovery of a Selective α5β1-Integrin Ligand as a Potent Tumor Imaging Agent. J Med Chem. 2018 Mar 22;61(6):2490-2499. DOI:10.1021/acs.jmedchem.7b01752 |
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