ChemicalBook--->CAS DataBase List--->756500-22-8

756500-22-8

756500-22-8 Structure

756500-22-8 Structure
IdentificationBack Directory
[Name]

cyclo (Arg-Gly-Asp-d-Phe-Glu)
[CAS]

756500-22-8
[Synonyms]

cyclo (Arg-Gly-Asp-d-Phe-Glu)
[Molecular Formula]

C26H36N8O9
[MOL File]

756500-22-8.mol
[Molecular Weight]

604.62
Chemical PropertiesBack Directory
[density ]

1.54±0.1 g/cm3(Predicted)
[form ]

Solid
[pka]

4.01±0.10(Predicted)
[color ]

White to off-white
[Sequence]

Cyclo(Arg-Gly-Asp-{d-Phe}-Glu)
[InChIKey]

LHYAAFPJZDQDLU-WHSWRCCXNA-N
[SMILES]

C(C1C=CC=CC=1)[C@H]1NC([C@@H](NC(CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(=O)O)NC1=O)=O)CC(=O)O)=O |&1:7,10,17,28,r|
Hazard InformationBack Directory
[Uses]

Cyclo(Arg-Gly-Asp-(D-Phe)-Glu) (c(RGDfE)) is a cyclic RGD peptide that serves as a conjugated multifunctional nanodrug delivery system to target Gemcitabine to pancreatic cancer cells. Cyclo(Arg-Gly-Asp-(D-Phe)-Glu) can be used in cancer research[1].
[References]

[1] Sun J , et al. A c(RGDfE) conjugated multi-functional nanomedicine delivery system for targeted pancreatic cancer therapy. J Mater Chem B. 2015 Feb 14;3(6):1049-1058. DOI:10.1039/c4tb01402b
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