| Identification | Back Directory | [Name]
Taxinine B | [CAS]
18457-44-8 | [Synonyms]
Taxane B
Taxinin B
Taxinine B
2-Propenoic acid, 3-phenyl-, (1S,3S,4aR,5R,6R,11R,12R,12aS)-1,5,11,12-tetrakis(acetyloxy)-1,2,3,4,4a,5,6,7,8,11,12,12a-dodecahydro-9,12a,13,13-tetramethyl-4-methylene-8-oxo-6,10-methanobenzocyclodecen-3-yl ester, (2E)- | [Molecular Formula]
C37H44O11 | [MDL Number]
MFCD17214888 | [MOL File]
18457-44-8.mol | [Molecular Weight]
664.74 |
| Chemical Properties | Back Directory | [Melting point ]
261-262 °C | [Boiling point ]
705.4±60.0 °C(Predicted) | [density ]
1.24±0.1 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder |
| Hazard Information | Back Directory | [Description]
Taxinine and taxinine B can inhibit the drug transport by P-glycoprotein in multidrug-resistant cells.
Taxinine B shows stronger inhibitory effects than acetylsalicylic acid (ASA) on platelet aggregation induced by arachidonic acid (AA). | [Uses]
Taxinine B is a taxoid that can be isolated from Japanese Yew Taxus Cuspid. Taxinine B inhibits CaCl2-induced depolymerization of microtubule. Taxinine B is useful for overcoming multidrug resistance in tumor cells[1]. | [References]
[1] Juníchi Kobayashi, et al. Taxuspines A ～ C, new taxoids from Japanese yew Taxus cuspidata inhibiting drug transport activity of P-glycoprotein in multidrug-resistant cells. Tetrahedron. 1994. 50 (25), 7401-7416. |
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