| Chemical Properties | Back Directory | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
Desiccate at -20°C | [form ]
Powder | [pka]
3.35±0.10(Predicted) | [color ]
White to off-white | [Water Solubility ]
Soluble to 5 mg/ml in water | [Sequence]
Ac-Lys-Arg-Pro-Pro-Gly-Phe-Ser-{d-βNal}-Ile |
| Hazard Information | Back Directory | [Description]
Potent and selective bradykinin B1receptor antagonist (pA2= 8.49). Displays no activity at B2receptors. Reduces mechanical hypernociception in a mouse model of neuropathic pain. Metabolically stable. | [Uses]
R715 is a selective bradykinin B1 receptor antagonist. R715 significantly attenuates the hyperalgesic effect developed in Streptozotocin(HY-13753)-diabetic mice[1]. | [storage]
Desiccate at -20°C | [References]
[1] Gabra BH, et al. Beneficial effect of chronic treatment with the selective bradykinin B1 receptor antagonists, R-715 and R-954, in attenuating streptozotocin-diabetic thermal hyperalgesia in mice. Peptides. 2003;24(8):1131-1139. DOI:10.1016/j.peptides.2003.06.003 |
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| Company Name: |
BOC Sciences
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| Website: |
https://www.bocsci.com |
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