| Identification | Back Directory | [Name]
Hit-1 | [CAS]
18508-77-5 | [Synonyms]
Hit-1
Illudalic acid
1,3,4,7,8,9-Hexahydro-3,6-dihydroxy-8,8-dimethyl-1-oxocyclopenta[h]-2-benzopyran-5-carbaldehyde
1-Oxo-3,6-dihydroxy-8,8-dimethyl-1,3,4,7,8,9-hexahydrocyclopenta[h]-2-benzopyran-5-carbaldehyde
Cyclopenta[h]-2-benzopyran-5-carboxaldehyde, 1,3,4,7,8,9-hexahydro-3,6-dihydroxy-8,8-dimethyl-1-oxo- | [Molecular Formula]
C15H16O5 | [MOL File]
18508-77-5.mol | [Molecular Weight]
276.28 |
| Hazard Information | Back Directory | [Uses]
Illudalic acid is a potent and selective Leukocyte antigen-related (LAR) phosphatase inhibitor with an IC50 value of 1.30 μM. Illudalic acid inhibits LAR phosphatase through covalent ligation to the catalytic cysteine residue[1][2]. | [References]
[1] Hansen DT, et al. The mechanism of covalent inhibition of LAR phosphatase by illudalic acid. Bioorg Med Chem Lett. 2024 May 15;104:129740. DOI:10.1016/j.bmcl.2024.129740
[2] Ling Q, et al. Illudalic acid as a potential LAR inhibitor: synthesis, SAR, and preliminary studies on the mechanism of action. Bioorg Med Chem. 2008 Aug 1;16(15):7399-409. DOI:10.1016/j.bmc.2008.06.014 |
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