1854985-74-2

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1854985-74-2 Structure

Identification	Back Directory
[Name] Lifirafenib maleate
[CAS] 1854985-74-2
[Synonyms] Lifirafenib maleate
[Molecular Formula] (C25H17F3N4O3)2. (C4H4O4)3
[MOL File] 1854985-74-2.mol
[Molecular Weight] 594.5

Hazard Information	Back Directory
[Uses] Lifirafenib (BGB-283) maleate is a novel and potent Raf Kinase and EGFR inhibitor with IC50 values of 23 and 29 nM for recombinant BRafV600E and EGFR, respectively[1].
[References] [1] Tang Z, et al. BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF-Mutated Colorectal Cancers. Mol Cancer Ther. 2015 Oct;14(10):2187-97. DOI:10.1158/1535-7163.MCT-15-0262

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