| Identification | Back Directory | [Name]
Asimadoline-HCl | [CAS]
185951-07-9 | [Synonyms]
Asimadoline-HCl
EMD-61753 hydrochloride
Asimadoline hydrochloride
Asimadoline Hydrochlorine
N-[(1S)-2-[(3S)-3-hydroxypyrrolidin-1-yl]-1-phenylethyl]-N-methyl-2,2-diphenylacetamide | [Molecular Formula]
C27H30N2O2 | [MDL Number]
MFCD28987467 | [MOL File]
185951-07-9.mol | [Molecular Weight]
414.539 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 240 mg/mL (532.15 mM) | [form ]
Solid | [color ]
Off-white to light yellow | [InChIKey]
GMJSLABTEURMBF-CLSOAGJSSA-N | [SMILES]
CN([C@H](CN1C[C@@H](O)CC1)C2=CC=CC=C2)C(C(C3=CC=CC=C3)C4=CC=CC=C4)=O.Cl |
| Hazard Information | Back Directory | [Uses]
Asimadoline Hydrochlorine is used in the treatment of IBS, a disorder associated with pain and altered bowel function. | [Biological Activity]
Asimadoline is a potent and selective K-opioid agonist th at does not penetrate the blood-brain barrier. Asimadoline produces both analgesic and antidiarrheal effects. | [in vivo]
Asimadoline (EMD-61753 hydrochloride; 1, 5, 15 mg/kg; s.c.) acutely ameliorates both formalin-evoked hyperalgesia and tactile allodynia in diabetic rats[3].
The absorption rate following oral administration is 80% in rats and >90% in dogs and monkeys. The metabolism of Asimadoline hydrochloride is rapid and appears similar in animals and man. Asimadoline hydrochloride has peripheral anti-inflammatory actions that are partly mediated through increase in joint fluid substance P levels[1].
Treatment with Asimadoline hydrochloride (5 mg/kg/day; i.p.) produces marked (and sustained) attenuation of the disease with all three time regimes[2].
| Animal Model: | Adult female Sprague-Dawley rats[3] | | Dosage: | 1, 5, 15 mg/kg | | Administration: | SC; single dose | | Result: | Acutely ameliorated both formalin-evoked hyperalgesia and tactile allodynia in diabetic rats.
|
| [IC 50]
κ Opioid Receptor/KOR |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
|